Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224996 | 0.90 | USP30 (0.42) | USP30PTPN1PTPN11CHRNB2CHRNA4 | |
| SCHEMBL7225141 | 0.89 | USP30 (0.44) | USP30PTPN1PTPN11MAPTSMN1; SMN2 | |
| SCHEMBL7234180 | 0.89 | USP30 (0.42) | USP30PTPN1PTPN11MAPTSMN1; SMN2 | |
| SCHEMBL7231198 | 0.89 | SMN1; SMN2 (0.47) | USP30PTPN1PTPN11MAPTSMN1; SMN2 | |
| SCHEMBL7226143 | 0.89 | PTPN11 (0.49) | USP30PTPN1PTPN11CHRNB2CHRNA4 | |
| SCHEMBL7071274 | 0.89 | USP30 (0.53) | USP30PTPN1CHRNB2CHRNA4MAPT | |
| SCHEMBL7223173 | 0.88 | CDC7 (0.43) | USP30PTPN1PTPN11GSK3BMAPT | |
| Hydrochloric Acid SCHEMBL7075524 | 0.88 | USP30 (0.52) | USP30PTPN1CHRNB2CHRNA4MAPT | |
| SCHEMBL7225292 | 0.88 | P2RX7 (0.43) | USP30CHRNB2CHRNA4GSK3BMAPT | |
| SCHEMBL7226045 | 0.88 | USP30 (0.43) | USP30PTPN1PTPN11MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |