Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PPIB | P23284 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937902 | 0.87 | MEN1 (0.71) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL1904635 | 0.87 | MEN1 (0.71) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL3143329 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4ETSHRL3MBTL1SPHK1 | |
| SCHEMBL1188654 | 0.87 | MEN1 (0.71) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL1627052 | 0.83 | MEN1 (0.77) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL7625352 | 0.82 | KDM4E (0.73) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL15652882 | 0.81 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2SPHK1 | |
| SCHEMBL11865724 | 0.80 | KDM4E (0.65) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL14711764 | 0.79 | F10 (0.47) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL2769755 | 0.79 | MEN1 (0.64) | ALDH1A1KDM4ETSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545035-B1 | Having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-04-08 | — | — | US | disclosed |
| US-6319918-B1 | FOR LYMPHOMA OR SOLID TUMORS TREATMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-11-20 | — | — | US | disclosed |
| CN-1303374-A | Substituted indolinones, process for their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA (DE) | 2001-07-11 | — | — | CN | disclosed |
| EP-1100779-A1 | SUBSTITUTED INDOLINONES, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2001-05-23 | — | — | EP | disclosed |
| WO-1999062882-A1 | SUBSTITUTED INDOLINONES, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-09 | — | — | WO | disclosed |