Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | FKBP1A | P62942 | 6/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10349406 | 0.89 | KDM4E (0.57) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL7449941 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL7484491 | 0.86 | MEN1 (0.80) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL1627052 | 0.86 | MEN1 (0.77) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7616379 | 0.84 | SMN1; SMN2 (0.60) | KDM4EALDH1A1SMN1; SMN2CD274HRH3 | |
| SCHEMBL7226548 | 0.82 | ALDH1A1 (0.67) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL21869793 | 0.82 | POLB (0.58) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL1188654 | 0.82 | MEN1 (0.71) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL4937902 | 0.82 | MEN1 (0.71) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL1904635 | 0.82 | MEN1 (0.71) | KDM4EALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436954-B1 | BENZO(B)QUINOLIZIDINE AND BENZO(F)INDOLIZIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA OR OTHER CONDITIONS CHARACTERIZED BY MEMORY LOSS; PYRROLO(1,2-B)ISOQUINOLINES, BENZO(B)QUINOLIZINES | AMERICAN BIOGENETIC SCIENCES, INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1098650-A1 | BENZOQUINOLIZIDINE AND BENZOINDOLIZIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004905-A1 | BENZOQUINOLIZIDINE AND BENZOINDOLIZIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2000-02-03 | — | — | WO | disclosed |