SCHEMBL7226905

SCHEMBL7226905

Cc1cc(C(=O)N[C@@H]2C[C@H]3CC[C@@H]2N3)sc1-c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.54
KDM4E B2RXH2 3/20 0.54
HTT P42858 3/20 0.54
HSD17B10 Q99714 3/20 0.54
MAPT P10636 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
ALDH1A1 P00352 2/20 0.43
LMNA P02545 2/20 0.43
TSHR P16473 2/20 0.43
USP2 O75604 1/20 0.43
ATM Q13315 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
POLB P06746 1/20 0.40
CCNA2 P20248 1/20 0.38
CDK2 P24941 1/20 0.38
KDR P35968 1/20 0.38
PLK1 P53350 1/20 0.38
CCNA1 P78396 1/20 0.38
DCLK1 O15075 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7225954 0.87 CCNA2 (0.38) HPGDKDM4EHTTHSD17B10MAPT
SCHEMBL7231989 0.86 CHRNA7 (0.39) HPGDKDM4EHTTHSD17B10MAPT
SCHEMBL7230705 0.85 HTR3E (0.39) CCNA2CDK2KDRPLK1CCNA1
SCHEMBL7234224 0.84 KDM1A (0.38) HPGDKDM4EHTTHSD17B10MAPT
SCHEMBL7225207 0.81 DAO (0.42) HTR3ACHRNA7
SCHEMBL7235019 0.80 CCNA2 (0.38) CCNA2CDK2KDRPLK1CCNA1
SCHEMBL7223552 0.80 NPC1 (0.38) HPGDHTTMAPTSMN1; SMN2NPC1
SCHEMBL7226779 0.80 HTR3E (0.41) CCNA2CDK2KDRPLK1CCNA1
SCHEMBL375517 0.80 CHRNA7 (0.57) HPGDKDM4EMAPTSMN1; SMN2NPC1
SCHEMBL7223338 0.80 CHRNA7 (0.57) HPGDKDM4EMAPTSMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6562816-B2 Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects PHARMACIA & UPJOHN COMPANY 2003-05-13 US claimed
US-6562816-B2 Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects PHARMACIA & UPJOHN COMPANY 2003-05-13 US disclosed