Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.36 |
| ▸ | HTR3B | O95264 | 4/20 | 0.36 |
| ▸ | HTR3A | P46098 | 4/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230705 | 0.87 | HTR3E (0.39) | CCNA2CDK2KDRPLK1CCNA1 | |
| SCHEMBL7225954 | 0.85 | CCNA2 (0.38) | CCNA2CDK2KDRPLK1CCNA1 | |
| SCHEMBL7226779 | 0.84 | HTR3E (0.41) | CCNA2CDK2KDRPLK1CCNA1 | |
| SCHEMBL7223931 | 0.84 | CTSC (0.39) | CCNA2CDK2KDRPLK1CCNA1 | |
| SCHEMBL7224419 | 0.81 | MEN1 (0.36) | AKT1HTR3ACHRNB2CHRNA4CHRNA7 | |
| SCHEMBL7225207 | 0.81 | DAO (0.42) | AKT1HTR3ACHRNB2CHRNA4CHRNA7 | |
| SCHEMBL7226905 | 0.80 | HPGD (0.54) | CCNA2CDK2KDRPLK1CCNA1 | |
| SCHEMBL375517 | 0.80 | CHRNA7 (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7223338 | 0.80 | CHRNA7 (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7225843 | 0.79 | USP30 (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |