Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 6/20 | 0.42 |
| ▸ | MAOB | P27338 | 6/20 | 0.42 |
| ▸ | KDM1A | O60341 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226904 | 1.00 | MCL1 (0.50) | MCL1BCL2L1FFAR1HDAC4ALDH1A1 | |
| SCHEMBL2507229 | 0.84 | MEN1 (0.48) | MCL1BCL2L1FFAR1HDAC4ALDH1A1 | |
| SCHEMBL3116465 | 0.84 | SLC9A1 (0.43) | MCL1FFAR1ALDH1A1GAACYP2C19 | |
| SCHEMBL1695729 | 0.84 | MEN1 (0.48) | MCL1BCL2L1FFAR1HDAC4ALDH1A1 | |
| SCHEMBL2507227 | 0.84 | MEN1 (0.48) | MCL1BCL2L1FFAR1HDAC4ALDH1A1 | |
| SCHEMBL7668951 | 0.81 | SLC6A3 (0.54) | CYP1A2CYP2D6CYP3A4SLC6A2SLC6A3 | |
| SCHEMBL3666782 | 0.81 | MAOB (0.54) | ALDH1A1MAPTKDM4EHPGDGAA | |
| SCHEMBL15831780 | 0.81 | MAOB (0.54) | ALDH1A1MAPTKDM4EHPGDGAA | |
| SCHEMBL7498817 | 0.79 | MCL1 (0.49) | MCL1BCL2L1FFAR1HDAC4ALDH1A1 | |
| SCHEMBL7498812 | 0.79 | MCL1 (0.49) | MCL1BCL2L1FFAR1HDAC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6538002-B1 | In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3. as antiinflammatory agents | MERCK & CO., INC. | 2003-03-25 | — | — | US | disclosed |
| US-6500844-B1 | PIPERIDINYL-1-METHYLCYCLOPENTANES AND STEREOISOMERS, USED AS ANTIINFLAMMATORY AND PROPHYLACTIC AGENTS AGAINST ALLERGIC RHINITIS, DERMATITIS, VISION DEFECTS, ASTHMA, ATHRITIS AND FOR PREVENTION OR DELAY OF AQUIRED IMMUNE DIFICIENCY SYNDROME | MERCK & CO., INC. | 2002-12-31 | — | — | US | disclosed |