Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 10/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25175773 | 0.87 | FFAR1 (0.42) | HAO1ALOX5GABRPGABRDGABRA1 | |
| SCHEMBL8002249 | 0.86 | HAO1 (0.44) | HAO1ALOX5 | |
| SCHEMBL25170006 | 0.81 | HAO1 (0.37) | HAO1ALOX5 | |
| SCHEMBL8537191 | 0.78 | BACE1 (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL28574194 | 0.78 | FABP7 (0.40) | HAO1EGFRHTR2CHTR2BBACE1 | |
| SCHEMBL23350659 | 0.74 | CHRM2 (0.54) | HAO1ASIC3CHRNB4CHRNA3EGFR | |
| SCHEMBL7092637 | 0.74 | CYP3A4 (0.42) | — | |
| SCHEMBL29215453 | 0.74 | EGFR (0.39) | EGFRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30311592 | 0.74 | EGFR (0.39) | EGFRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10422902 | 0.74 | HTR2C (0.38) | CHRNB4CHRNA3EGFRGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610722-B2 | Peptidomimetic macrocyclic compounds that comprise a bicyclic imidazolyl moiety and that do not contain thiol moieties; e.g., 3,5-ethano-6,10:12,16-dimetheno-22H-imidazo (3,4-h)(1,8,11,14)oxatriazacycloeicosine-9-carbonitrile | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| US-20020068747-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2002-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068747-A1 | Inhibitors of prenyl-protein transferase | FNTA, KRAS, NRAS | HAO1 4187/4885ASIC3 4824/4885CHRNB4 4734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.