Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222661 | 0.86 | POLH (0.62) | POLHABCB1NPC1KMT2ARAB9A | |
| SCHEMBL7221113 | 0.85 | NPC1 (0.69) | POLHABCB1NPC1KMT2ARAB9A | |
| SCHEMBL7220763 | 0.85 | POLH (0.58) | POLHABCB1NPC1KMT2ARAB9A | |
| SCHEMBL7221925 | 0.75 | NPC1 (0.62) | NPC1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL7221843 | 0.74 | NPC1 (0.63) | NPC1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL7220774 | 0.73 | POLH (0.52) | POLHABCB1NPC1KMT2ARAB9A | |
| SCHEMBL25263266 | 0.73 | POLH (1.00) | POLHABCB1NPC1KMT2ARAB9A | |
| SCHEMBL30663840 | 0.73 | POLH (1.00) | POLHABCB1NPC1KMT2ARAB9A | |
| SCHEMBL7229907 | 0.71 | MAOB (0.63) | ABCB1NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL7221186 | 0.71 | NPC1 (0.75) | ABCB1NPC1KMT2ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552054-B1 | For prophylaxis and therapy of bone diseases and chondropathy | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-22 | — | — | US | disclosed |