Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221113 | 0.89 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL7221843 | 0.87 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL7221186 | 0.81 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL7222661 | 0.80 | POLH (0.62) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL7220763 | 0.77 | POLH (0.58) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL7227797 | 0.75 | POLH (0.56) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL7228016 | 0.73 | POLH (0.45) | ALOX5ACHEALDH1A1MAPT | |
| SCHEMBL7220707 | 0.71 | HIF1A (0.53) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| Hydrochloric Acid SCHEMBL7221509 | 0.71 | HIF1A (0.54) | NPC1RAB9ASMN1; SMN2MAPK1TP53 | |
| SCHEMBL7229907 | 0.70 | MAOB (0.63) | NPC1RAB9ASMN1; SMN2MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552054-B1 | For prophylaxis and therapy of bone diseases and chondropathy | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-22 | — | — | US | claimed |
| EP-1211251-A1 | CHROMONE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | claimed |
| US-6552054-B1 | For prophylaxis and therapy of bone diseases and chondropathy | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| EP-1211251-A1 | CHROMONE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |