Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 1.00 |
| ▸ | ESR1 | P03372 | 3/20 | 0.68 |
| ▸ | MAOA | P21397 | 5/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | CASP7 | P55210 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246696 | 0.84 | ESR2 (0.71) | ESR2ESR1MAOAKDM4EMAPT | |
| SCHEMBL7228385 | 0.81 | ESR2 (1.00) | ESR2ESR1MAOAMAPTCYP3A4 | |
| SCHEMBL7227909 | 0.80 | ESR2 (0.67) | ESR2ESR1MAOANPSR1KDM4E | |
| SCHEMBL7234834 | 0.75 | ESR2 (0.77) | ESR2ESR1MAOANPSR1RXFP1 | |
| SCHEMBL7237389 | 0.75 | ESR2 (0.77) | ESR2ESR1MAOANPSR1RXFP1 | |
| SCHEMBL2299504 | 0.74 | MAOA (1.00) | ESR2ESR1MAOANPSR1RXFP1 | |
| SCHEMBL29715739 | 0.74 | MAOA (1.00) | ESR2ESR1MAOANPSR1RXFP1 | |
| SCHEMBL7228411 | 0.72 | ESR2 (0.83) | ESR2ESR1MAOAKDM4EMAPT | |
| SCHEMBL7339338 | 0.72 | MAOA (1.00) | ESR2ESR1MAOANPSR1RXFP1 | |
| SCHEMBL30468736 | 0.71 | MAOA (0.81) | ESR2ESR1MAOANPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559177-B2 | For therapy or inhibiting osteoporosis or inhibiting bone demineralization, inflammatory bowel disease, Crohn's disease, ulcerative proctitis, or colitis in mammal | WYETH | 2003-05-06 | — | — | US | claimed |
| US-20020183310-A1 | 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents | WYETH | 2002-12-05 | — | — | US | claimed |
| US-6559177-B2 | For therapy or inhibiting osteoporosis or inhibiting bone demineralization, inflammatory bowel disease, Crohn's disease, ulcerative proctitis, or colitis in mammal | WYETH | 2003-05-06 | — | — | US | disclosed |
| US-20020183310-A1 | 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents | WYETH | 2002-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183310-A1 | 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents | ESR1, GPER1, ESR2 | ESR2 3/4885ESR1 1/4885MAOA 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.