Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 5/20 | 1.00 |
| ▸ | ESR1 | P03372 | 3/20 | 1.00 |
| ▸ | MAOA | P21397 | 6/20 | 0.59 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.59 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.59 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.59 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.59 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.59 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.59 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.59 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.59 |
| ▸ | MGAM | O43451 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SI | P14410 | 2/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | CLK3 | P49761 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228032 | 0.81 | ESR2 (1.00) | ESR2ESR1MAOAMGAMGAA | |
| SCHEMBL7235669 | 0.76 | ESR2 (1.00) | ESR2ESR1MAOAATP1A1ATP1B1 | |
| SCHEMBL7246696 | 0.75 | ESR2 (0.71) | ESR2ESR1MAOACYP3A4MAPT | |
| SCHEMBL29396825 | 0.75 | MAOA (1.00) | ESR2ESR1MAOAATP1A1ATP1B1 | |
| SCHEMBL4743861 | 0.75 | MAOA (1.00) | ESR2ESR1MAOAATP1A1ATP1B1 | |
| SCHEMBL2314333 | 0.74 | MGAM (1.00) | ESR2ESR1MAOAATP1A1ATP1B1 | |
| SCHEMBL30346407 | 0.74 | MGAM (1.00) | ESR2ESR1MAOAATP1A1ATP1B1 | |
| SCHEMBL11027790 | 0.73 | MAOA (0.70) | ESR2ESR1MAOAATP1A1ATP1B1 | |
| SCHEMBL28020193 | 0.73 | MGAM (0.97) | ESR2ESR1MAOAATP1A1ATP1B1 | |
| SCHEMBL7236938 | 0.73 | MAOA (0.62) | ESR2ESR1MAOAMGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559177-B2 | For therapy or inhibiting osteoporosis or inhibiting bone demineralization, inflammatory bowel disease, Crohn's disease, ulcerative proctitis, or colitis in mammal | WYETH | 2003-05-06 | — | — | US | disclosed |
| US-20020183310-A1 | 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents | WYETH | 2002-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183310-A1 | 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents | ESR1, GPER1, ESR2 | ESR2 3/4885ESR1 1/4885MAOA 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.