Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7231883 | 0.99 | PIK3CA (0.38) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| SCHEMBL7238640 | 0.83 | KMT2A (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| Hydrochloric Acid SCHEMBL7239873 | 0.83 | NR2F2 (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| SCHEMBL10667475 | 0.83 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| SCHEMBL7240091 | 0.81 | CDK4 (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| SCHEMBL7229068 | 0.81 | PIK3CA (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| Hydrochloric Acid SCHEMBL7238261 | 0.80 | NR2F2 (0.39) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| SCHEMBL7239807 | 0.78 | ALDH1A1 (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| SCHEMBL7240097 | 0.76 | PIK3CA (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 | |
| SCHEMBL7229076 | 0.76 | PIK3CA (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGNR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |