Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10667475 | 0.87 | PIK3CA (0.41) | ALDH1A1SMN1; SMN2MAPTPIK3CAPIK3CG | |
| SCHEMBL7229076 | 0.85 | PIK3CA (0.40) | ALDH1A1SMN1; SMN2MAPTPIK3CAPIK3CG | |
| SCHEMBL7240097 | 0.85 | PIK3CA (0.40) | ALDH1A1SMN1; SMN2MAPTPIK3CAPIK3CG | |
| SCHEMBL7229068 | 0.82 | PIK3CA (0.40) | ALDH1A1SMN1; SMN2MAPTPIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL7239873 | 0.82 | NR2F2 (0.41) | ALDH1A1SMN1; SMN2HTTMAPTPIK3CA | |
| SCHEMBL7240091 | 0.81 | CDK4 (0.40) | ALDH1A1SMN1; SMN2MAPTPIK3CAPIK3CG | |
| SCHEMBL7237020 | 0.81 | RAB9A (0.65) | ALDH1A1SMN1; SMN2MAPTGAAMEN1 | |
| Hydrochloric Acid SCHEMBL7238261 | 0.79 | NR2F2 (0.39) | ALDH1A1SMN1; SMN2HTTMAPTPIK3CA | |
| SCHEMBL7238640 | 0.78 | KMT2A (0.40) | ALDH1A1SMN1; SMN2HTTMAPTPIK3CA | |
| SCHEMBL7229274 | 0.78 | PIK3CA (0.39) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |