Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.81 |
| ▸ | MMP3 | P08254 | 11/20 | 0.81 |
| ▸ | MMP9 | P14780 | 11/20 | 0.81 |
| ▸ | MMP13 | P45452 | 10/20 | 0.81 |
| ▸ | MMP1 | P03956 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229700 | 0.90 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7230785 | 0.89 | MMP2 (0.65) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7222943 | 0.88 | MMP2 (0.64) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7222383 | 0.87 | MMP2 (0.65) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7232020 | 0.87 | MMP2 (0.63) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7229433 | 0.85 | MMP2 (0.62) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6300844 | 0.84 | MMP2 (0.61) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7894228 | 0.83 | MMP2 (0.61) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7893160 | 0.83 | MMP2 (0.61) | MMP2MMP3MMP9MMP13MMP1 | |
| Trifluoroacetic Acid SCHEMBL7224205 | 0.83 | MMP2 (0.58) | MMP2MMP3MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |