Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.63 |
| ▸ | MMP3 | P08254 | 7/20 | 0.63 |
| ▸ | MMP9 | P14780 | 7/20 | 0.63 |
| ▸ | MMP13 | P45452 | 7/20 | 0.63 |
| ▸ | MMP1 | P03956 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229291 | 0.87 | MMP2 (0.81) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7230785 | 0.85 | MMP2 (0.65) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7222943 | 0.85 | MMP2 (0.64) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7222383 | 0.84 | MMP2 (0.65) | MMP2MMP3MMP9MMP13MMP1 | |
| Trifluoroacetic Acid SCHEMBL7224205 | 0.80 | MMP2 (0.58) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7232017 | 0.79 | MMP2 (0.47) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7224892 | 0.79 | MMP2 (0.57) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7229700 | 0.78 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL874192 | 0.77 | MMP2 (0.56) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL877664 | 0.74 | MMP2 (0.52) | MMP2MMP3MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |