Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846603 | 0.83 | SLC29A1 (0.47) | ALDH1A1MAPTMAPK1RAB9AADORA1 | |
| SCHEMBL6846871 | 0.81 | LMNA (0.45) | ALDH1A1MAPTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL6844806 | 0.78 | GAA (0.50) | ALDH1A1MAPTMAPK1ROCK2POLB | |
| SCHEMBL6846844 | 0.77 | MAPT (0.47) | ALDH1A1MAPTMAPK1RAB9ACSNK2A2 | |
| SCHEMBL6846427 | 0.77 | NPC1 (0.50) | ALDH1A1MAPTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL6846446 | 0.77 | PAK1 (0.35) | ALDH1A1MAPTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL6841315 | 0.76 | ALDH1A1 (0.48) | ALDH1A1MAPTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL7592061 | 0.76 | ALDH1A1 (0.48) | ALDH1A1MAPTMAPK1RAB9ACSNK2A1 | |
| SCHEMBL6845380 | 0.76 | ALDH1A1 (0.49) | ALDH1A1MAPTMAPK1RAB9ACDC7 | |
| SCHEMBL6846677 | 0.75 | ALDH1A1 (0.48) | ALDH1A1MAPTMAPK1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6635641-B2 | For treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, psoriasis | AGOURON PHARMACEUTICALS, INC. | 2003-10-21 | — | — | US | disclosed |
| EP-1252146-A1 | AMIDE COMPOUNDS FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001053274-A1 | AMIDE COMPOUNDS FOR INHIBITING PROTEIN KINASES | AGOURON PHARMACEUTICALS, INC. (US) | 2001-07-26 | — | — | WO | disclosed |