Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP3 | P08254 | 4/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222940 | 0.81 | ALDH1A1 (0.42) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7230732 | 0.75 | MMP2 (0.66) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7224498 | 0.75 | MMP2 (0.52) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7226543 | 0.73 | GAA (0.45) | MMP2MMP9GAASMN1; SMN2 | |
| SCHEMBL7225944 | 0.72 | MMP2 (0.43) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7231966 | 0.65 | MMP2 (0.42) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7231569 | 0.64 | MMP2 (0.53) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7224275 | 0.64 | MMP2 (0.54) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7223468 | 0.64 | MMP2 (0.69) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7233440 | 0.62 | MMP2 (0.81) | MMP2MMP3MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |
| EP-1091937-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000473-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2000-01-06 | — | — | WO | disclosed |