Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222633 | 0.89 | MRGPRX1 (0.33) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL7225638 | 0.89 | SMN1; SMN2 (0.36) | ALDH1A1CHRNA7CXCR2HTR3EHTR3B | |
| SCHEMBL7223853 | 0.85 | CHRNA7 (0.43) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7225513 | 0.85 | CHRNA7 (0.37) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224194 | 0.84 | CHRNA7 (0.35) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7230631 | 0.84 | CHRNA7 (0.33) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7232302 | 0.84 | CHRNA7 (0.36) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7232082 | 0.84 | CXCR2 (0.34) | ALDH1A1CHRNA7CXCR2MRGPRX1HTR3E | |
| SCHEMBL7224864 | 0.84 | ANO1 (0.35) | CHRNA7CXCR2MRGPRX1 | |
| SCHEMBL7234424 | 0.84 | F2 (0.35) | ALDH1A1HSD17B10KDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |