Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | PRKCB | P05771 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
| ▸ | MLYCD | O95822 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225638 | 0.89 | SMN1; SMN2 (0.36) | CXCR2SMN1; SMN2CHRNA7GAAPKM | |
| SCHEMBL7232082 | 0.88 | CXCR2 (0.34) | CXCR2MRGPRX1SMN1; SMN2CHRNA7GAA | |
| SCHEMBL7232823 | 0.86 | EPHX2 (0.36) | CHRNA7SLC6A3 | |
| SCHEMBL7222633 | 0.86 | MRGPRX1 (0.33) | CXCR2MRGPRX1CHRNA7PRKCB | |
| SCHEMBL7231099 | 0.84 | L3MBTL1 (0.34) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7229598 | 0.84 | ALDH1A1 (0.42) | CXCR2MRGPRX1CHRNA7 | |
| SCHEMBL7222908 | 0.84 | EPHX2 (0.34) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL7224194 | 0.83 | CHRNA7 (0.35) | CHRNA7SLC6A3 | |
| SCHEMBL7223114 | 0.83 | CHRNA7 (0.40) | SMN1; SMN2CHRNA7TP53MAPT | |
| SCHEMBL7223853 | 0.82 | CHRNA7 (0.43) | SMN1; SMN2CHRNA7SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |