SCHEMBL7230301

SCHEMBL7230301

CCOC(=O)c1cnn(-c2ccnc(O)n2)c1C

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.51
NPC1 O15118 5/20 0.51
HPGD P15428 2/20 0.51
TP53 P04637 1/20 0.51
MAPT P10636 5/20 0.49
ALDH1A1 P00352 6/20 0.46
SMN1; SMN2 Q16637 5/20 0.45
TSHR P16473 3/20 0.45
KMT2A Q03164 2/20 0.45
MEN1 O00255 1/20 0.45
KDM4E B2RXH2 2/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
HTT P42858 1/20 0.42
PTGS2 P35354 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7232416 0.86 NPC1 (0.50) RAB9ANPC1HPGDTP53MAPT
SCHEMBL7239669 0.80 NPC1 (0.49) RAB9ANPC1HPGDTP53MAPT
SCHEMBL120748 0.80 RAB9A (0.77) RAB9ANPC1HPGDTP53MAPT
SCHEMBL15167811 0.80 RAB9A (0.55) RAB9ANPC1HPGDTP53MAPT
SCHEMBL15167255 0.78 RAB9A (0.56) RAB9ANPC1HPGDTP53MAPT
SCHEMBL3998143 0.78 MAPT (0.55) RAB9ANPC1HPGDTP53MAPT
SCHEMBL17395647 0.78 MAPT (0.55) RAB9ANPC1HPGDTP53MAPT
SCHEMBL15167788 0.78 ALDH1A1 (0.52) RAB9ANPC1HPGDTP53MAPT
SCHEMBL20278455 0.78 MAPT (0.49) RAB9ANPC1HPGDTP53MAPT
SCHEMBL15166924 0.78 MAPT (0.49) RAB9ANPC1HPGDTP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6552018-B1 As antitumor agents DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2003-04-22 US disclosed
CN-1105707-C Pyrazole derivative DAIICHI SEIYAKU CO (JP) 2003-04-16 CN disclosed
US-6169086-B1 AN ANTITUMOR AGENT FOR TREATING TUMOR RESISTANT TO 5-FLUOROURACIL TYPE DRUGS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
EP-1022270-A1 PYRAZOLE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-07-26 EP disclosed
CN-1251578-A Pyrazole derivative DAIICHI SEIYAKU CO (JP) 2000-04-26 CN disclosed