Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232501 | 0.80 | PDE4D (0.48) | ALDH1A1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7230885 | 0.79 | CYP17A1 (0.34) | MAP4K4ALDH1A1POLBGFERKARS1 | |
| SCHEMBL7236710 | 0.73 | NPFFR1 (0.34) | — | |
| SCHEMBL7230871 | 0.66 | MAP4K4 (0.50) | MAP4K4ALDH1A1POLBGFERSYK | |
| SCHEMBL7230492 | 0.66 | MAP4K4 (0.43) | MAP4K4ALDH1A1POLBGFERMEN1 | |
| SCHEMBL7229215 | 0.64 | CYP2A6 (0.56) | MAP4K4ALDH1A1POLBGFERMEN1 | |
| SCHEMBL23670989 | 0.63 | ASIC3 (0.50) | MAP4K4ALDH1A1POLBGFERKARS1 | |
| SCHEMBL27339880 | 0.63 | MAP4K4 (0.58) | MAP4K4ALDH1A1POLBGFERMEN1 | |
| SCHEMBL29161794 | 0.62 | MAOA (0.42) | MAP4K4ALDH1A1GFERMEN1PSIP1 | |
| SCHEMBL2686693 | 0.62 | MAP4K4 (0.58) | MAP4K4MEN1PSIP1AXLMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |