Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.62 |
| ▸ | PLK1 | P53350 | 14/20 | 0.47 |
| ▸ | KDR | P35968 | 9/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242766 | 0.91 | FYN (0.60) | FYNPLK1KDR | |
| Hydrochloric Acid SCHEMBL7233397 | 0.88 | FYN (0.60) | FYNPLK1KDR | |
| Hydrochloric Acid SCHEMBL7232727 | 0.84 | FYN (0.58) | FYNPLK1KDR | |
| SCHEMBL7241122 | 0.83 | FYN (0.65) | FYNPLK1KDRPDGFRB | |
| Hydrochloric Acid SCHEMBL7240520 | 0.83 | FYN (0.56) | FYNPLK1KDRPDGFRB | |
| SCHEMBL7240926 | 0.83 | FYN (0.57) | FYNPLK1KDR | |
| Hydrochloric Acid SCHEMBL7240228 | 0.83 | FYN (0.65) | FYNPLK1KDR | |
| Hydrochloric Acid SCHEMBL7232574 | 0.83 | PLK1 (0.64) | FYNPLK1KDR | |
| SCHEMBL7230541 | 0.82 | FYN (0.57) | FYNPLK1KDRPDGFRBPLK3 | |
| SCHEMBL7234532 | 0.82 | FYN (0.55) | FYNPLK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |