Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.33 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
| ▸ | HTR3B | O95264 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.30 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231963 | 0.87 | ESR1 (0.37) | SLC6A3SLC6A2SLC6A4ESRRGALDH1A1 | |
| SCHEMBL7231965 | 0.87 | CHRNA7 (0.36) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL7231859 | 0.85 | HDAC3 (0.34) | SLC6A3SLC6A2SLC6A4TSHRHSD17B10 | |
| SCHEMBL7234021 | 0.85 | SLC6A3 (0.39) | SLC6A3SLC6A2SLC6A4TSHRALDH1A1 | |
| SCHEMBL7232207 | 0.85 | SLC6A2 (0.39) | SLC6A3SLC6A2SLC6A4TSHRHPGD | |
| SCHEMBL7224995 | 0.85 | CHRNA7 (0.34) | SLC6A3SLC6A2SLC6A4ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7231366 | 0.84 | SLC6A3 (0.38) | SLC6A3SLC6A2SLC6A4TSHRALDH1A1 | |
| SCHEMBL7233055 | 0.83 | HPGD (0.36) | SLC6A3SLC6A2SLC6A4ALDH1A1HPGD | |
| SCHEMBL7225934 | 0.83 | SLC6A2 (0.30) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL7231256 | 0.83 | CHRNB2 (0.35) | SLC6A3SLC6A2SLC6A4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |