Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225431 | 0.89 | CHRNB2 (0.31) | HPGD | |
| SCHEMBL7224231 | 0.88 | KDM1A (0.32) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7231839 | 0.86 | KDM1A (0.32) | NPC1RAB9ATP53HPGDTSHR | |
| SCHEMBL7230672 | 0.85 | NPC1 (0.31) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7224129 | 0.83 | NPC1 (0.32) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7233342 | 0.83 | NPC1 (0.33) | NPC1RAB9ATP53HPGDTSHR | |
| SCHEMBL7232492 | 0.83 | CHRNB2 (0.31) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7225000 | 0.83 | NPC1 (0.34) | NPC1RAB9ASMN1; SMN2SMYD3SLC6A2 | |
| SCHEMBL7224163 | 0.83 | CHRNA7 (0.32) | — | |
| SCHEMBL7230402 | 0.82 | SLC6A2 (0.34) | NPC1RAB9AHPGDSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |