Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226061 | 0.86 | MEN1 (0.48) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL5219336 | 0.85 | TPMT (0.48) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL29805501 | 0.84 | KDM4E (0.60) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL1481655 | 0.83 | KMT2A (0.59) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL7240806 | 0.81 | KDM4E (0.65) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL195322 | 0.80 | ALDH1A1 (0.70) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL15596207 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1MAPTSMN1; SMN2HPGD | |
| Methylpyrrolidone SCHEMBL27622825 | 0.79 | KMT2A (0.49) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL14334778 | 0.78 | MAPT (0.53) | MEN1KMT2AKDM4EGAAALDH1A1 | |
| SCHEMBL1479619 | 0.78 | RAB9A (0.53) | KDM4EALDH1A1MAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509359-B1 | Use as a neuramninidase inhibitor in virus | BIOCRYST PHARMACEUTICALS, INC. | 2003-01-21 | — | — | US | disclosed |
| WO-1999014191-A1 | PYRROLIDIN-2-ONE COMPOUNDS AND THEIR USE AS NEURAMINIDASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 1999-03-25 | — | — | WO | disclosed |