Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 9/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 9/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 9/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230932 | 1.00 | HRH4 (0.48) | HRH4NUDT1PTGER4PTGER2PTGER3 | |
| SCHEMBL7236662 | 0.87 | HRH4 (0.49) | HRH4NUDT1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7236669 | 0.87 | HRH4 (0.49) | HRH4NUDT1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7231178 | 0.87 | HRH4 (0.53) | HRH4NUDT1ALDH1A1PKMNPC1 | |
| SCHEMBL7236175 | 0.80 | MAPT (0.52) | HRH4NUDT1ALDH1A1LMNANPC1 | |
| SCHEMBL27469144 | 0.79 | HRH4 (0.48) | HRH4NUDT1ALDH1A1LMNANPC1 | |
| SCHEMBL7167083 | 0.76 | HRH4 (0.48) | HRH4NUDT1KDM4ELMNAHPGD | |
| SCHEMBL7167081 | 0.76 | HRH4 (0.48) | HRH4NUDT1KDM4ELMNAHPGD | |
| SCHEMBL7230951 | 0.67 | CCNC (0.38) | NPC1RAB9A | |
| SCHEMBL26660073 | 0.67 | NUDT1 (0.67) | HRH4NUDT1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552018-B1 | As antitumor agents | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| US-6169086-B1 | AN ANTITUMOR AGENT FOR TREATING TUMOR RESISTANT TO 5-FLUOROURACIL TYPE DRUGS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-1022270-A1 | PYRAZOLE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-26 | — | — | EP | disclosed |