Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27469144 | 0.82 | HRH4 (0.48) | MAPTNPC1TSHRCYP1A2CYP2C19 | |
| SCHEMBL7231178 | 0.80 | HRH4 (0.53) | MAPTNPC1TSHRCYP1A2CYP2C19 | |
| SCHEMBL7230918 | 0.80 | HRH4 (0.48) | NPC1HPGDALDH1A1RAB9AHRH4 | |
| SCHEMBL7230932 | 0.80 | HRH4 (0.48) | NPC1HPGDALDH1A1RAB9AHRH4 | |
| SCHEMBL7239669 | 0.79 | NPC1 (0.49) | MAPTNPC1TSHRCYP1A2CYP2C19 | |
| SCHEMBL7242010 | 0.79 | ALKBH1 (0.53) | MAPTNPC1TSHRCYP1A2CYP2C19 | |
| SCHEMBL7171257 | 0.78 | TSHR (0.55) | MAPTNPC1TSHRCYP1A2CYP2C19 | |
| SCHEMBL7236662 | 0.77 | HRH4 (0.49) | TSHRCYP1A2CYP2C19ALDH1A1HRH4 | |
| SCHEMBL7236669 | 0.77 | HRH4 (0.49) | TSHRCYP1A2CYP2C19ALDH1A1HRH4 | |
| SCHEMBL18689771 | 0.75 | KMT2A (0.44) | MAPTNPC1HPGDALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552018-B1 | As antitumor agents | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| CN-1105707-C | Pyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2003-04-16 | — | — | CN | disclosed |
| US-6169086-B1 | AN ANTITUMOR AGENT FOR TREATING TUMOR RESISTANT TO 5-FLUOROURACIL TYPE DRUGS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-1022270-A1 | PYRAZOLE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-26 | — | — | EP | disclosed |
| CN-1251578-A | Pyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2000-04-26 | — | — | CN | disclosed |