Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 3/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.45 |
| ▸ | HTR3B | O95264 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235830 | 0.89 | CAPN1 (0.56) | CAPN1CTSSCHIATSHRHSD17B10 | |
| SCHEMBL7238735 | 0.86 | CAPN1 (0.53) | CAPN1CTSSTSHRHSD17B10HTR3E | |
| SCHEMBL7243415 | 0.85 | CAPN1 (0.47) | CAPN1CTSSCHIATSHRHSD17B10 | |
| SCHEMBL7238926 | 0.84 | CAPN1 (0.49) | CAPN1CTSSHSD17B10BCHEMAPT | |
| SCHEMBL7235461 | 0.81 | CAPN1 (0.47) | CAPN1CTSSCHIATSHRHSD17B10 | |
| SCHEMBL7243236 | 0.81 | L3MBTL1 (0.49) | CAPN1CTSSTSHRHSD17B10MAPT | |
| SCHEMBL7235428 | 0.81 | CAPN1 (0.57) | CAPN1CTSSTSHRHSD17B10 | |
| SCHEMBL7242743 | 0.81 | TSHR (0.54) | CAPN1CTSSCHIATSHRHSD17B10 | |
| SCHEMBL7242851 | 0.81 | CHIA (0.58) | CAPN1CTSSCHIATSHRHSD17B10 | |
| SCHEMBL7241450 | 0.80 | CTSL (0.52) | CAPN1CTSSTSHRBCHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |