Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.56 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.56 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.56 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.51 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.51 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235013 | 0.87 | TP53 (0.62) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL7320311 | 0.86 | ORAI1 (0.67) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL7319407 | 0.86 | TP53 (0.64) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL7315526 | 0.86 | TP53 (0.71) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL7314472 | 0.86 | TP53 (0.67) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL7313426 | 0.83 | ORAI1 (0.67) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL7321880 | 0.82 | ORAI1 (1.00) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL5208645 | 0.82 | ORAI1 (1.00) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL7325234 | 0.81 | ORAI1 (0.67) | ORAI1TP53MAPTTHRBTRPC3 | |
| SCHEMBL7322521 | 0.81 | ORAI1 (0.58) | ORAI1TP53MAPTTHRBTRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506747-B1 | Method of treating an inflammatory disease which comprises administering to a patient in need of such treatment-a N-(4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl)pyridine-3-carboxamide; | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-01-14 | — | — | US | disclosed |