Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.64 |
| ▸ | THRB | P10828 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.60 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.60 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.60 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.59 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.59 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.59 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319407 | 0.90 | TP53 (0.64) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7320311 | 0.90 | ORAI1 (0.67) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7235013 | 0.88 | TP53 (0.62) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7320557 | 0.88 | ORAI1 (0.79) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7314472 | 0.86 | TP53 (0.67) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7233105 | 0.86 | ORAI1 (0.70) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7313426 | 0.86 | ORAI1 (0.67) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7328606 | 0.85 | THRB (0.59) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7314688 | 0.85 | TP53 (0.56) | TP53MAPTORAI1THRBNPC1 | |
| SCHEMBL7323681 | 0.84 | KDM4E (0.69) | TP53MAPTORAI1THRBTRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | claimed |
| EP-1068187-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 2001-01-17 | — | — | EP | claimed |
| WO-1999051580-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 1999-10-14 | — | — | WO | claimed |
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES | 2001-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044445-A1 | AZOLE INHIBITORS OF CYTOKINE PRODUCTION | IL5, IL2, IL4 | TP53 1903/4885MAPT 2674/4885ORAI1 3522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.