Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225106 | 0.91 | DGAT1 (0.44) | DGAT1USP30CHRNB2CHRNA4ULK1 | |
| SCHEMBL7231136 | 0.88 | DGAT1 (0.41) | DGAT1USP30CHRNB2CHRNA4 | |
| SCHEMBL7225968 | 0.88 | USP30 (0.43) | DGAT1USP30CHRNB2CHRNA4ULK1 | |
| SCHEMBL7232956 | 0.87 | DGAT1 (0.41) | DGAT1USP30CHRNB2CHRNA4 | |
| SCHEMBL7232544 | 0.87 | DGAT1 (0.44) | DGAT1USP30CHRNB2CHRNA4ULK1 | |
| SCHEMBL7226585 | 0.87 | DGAT1 (0.41) | DGAT1USP30 | |
| SCHEMBL7234821 | 0.87 | HDAC1 (0.43) | DGAT1USP30CHRNB2CHRNA4 | |
| SCHEMBL7233420 | 0.87 | USP30 (0.43) | DGAT1USP30 | |
| SCHEMBL7235102 | 0.87 | USP30 (0.52) | DGAT1USP30CHRNB2CHRNA4 | |
| SCHEMBL7225214 | 0.86 | USP30 (0.39) | DGAT1USP30CHRNB2CHRNA4ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |