Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 2/20 | 0.60 |
| ▸ | FGF1 | P05230 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TIMP3 | P35625 | 3/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | RHOA | P61586 | 1/20 | 0.49 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224393 | 0.93 | CASP6 (0.58) | CASP6FGF1NPC1RAB9ACYP1A2 | |
| SCHEMBL7223574 | 0.93 | FGF1 (0.60) | CASP6FGF1NPC1RAB9ACYP1A2 | |
| SCHEMBL4119552 | 0.92 | CASP6 (0.67) | CASP6FGF1NPC1RAB9ACYP1A2 | |
| SCHEMBL7223972 | 0.91 | FGF1 (0.63) | CASP6FGF1NPC1RAB9ACYP1A2 | |
| SCHEMBL7224663 | 0.90 | CASP6 (0.55) | CASP6FGF1NPC1RAB9ACYP1A2 | |
| SCHEMBL6240628 | 0.90 | CASP6 (0.72) | CASP6FGF1NPC1RAB9ACYP1A2 | |
| SCHEMBL7230329 | 0.90 | CASP6 (0.57) | CASP6FGF1NPC1RAB9ACYP1A2 | |
| SCHEMBL7224369 | 0.90 | CASP6 (0.57) | CASP6FGF1NPC1RAB9ATIMP3 | |
| SCHEMBL7233109 | 0.90 | FGF1 (0.59) | CASP6FGF1NPC1RAB9ACYP1A2 | |
| SCHEMBL7233931 | 0.90 | CASP6 (0.57) | CASP6FGF1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653321-B1 | Stimulating kinase activity of insulin receptor; type II diabetes; hyperglycemia | TELIK, INC. | 2003-11-25 | — | — | US | disclosed |