Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 9/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697906 | 0.82 | NPC1 (0.52) | NPC1RAB9AKDM4EMAPTGFER | |
| SCHEMBL702798 | 0.80 | NPY5R (0.57) | NPY5RPARP1PARP2MAPTHTR2B | |
| SCHEMBL2706414 | 0.74 | MAPT (0.48) | NPY5RNPC1RAB9AKDM4EMAPT | |
| SCHEMBL15200719 | 0.67 | ALDH1A1 (0.31) | NPC1RAB9AKDM4EKMT2A | |
| SCHEMBL1443559 | 0.65 | ESR2 (0.39) | — | |
| SCHEMBL15766752 | 0.64 | NPY5R (0.47) | NPY5RNPC1RAB9AKDM4EHTR2B | |
| SCHEMBL2276872 | 0.63 | ALDH1A1 (0.59) | NPY5RNPC1RAB9AKDM4EMAPT | |
| SCHEMBL2562588 | 0.63 | — | — | |
| SCHEMBL2564874 | 0.63 | ALDH1A1 (0.53) | KDM4EMAPTKMT2A | |
| SCHEMBL314691 | 0.63 | ALDH1A1 (0.43) | PARP1NPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |