Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276872 | 0.85 | ALDH1A1 (0.59) | NPY5RKMT2AHTR2BPKMALDH1A1 | |
| SCHEMBL15766752 | 0.84 | NPY5R (0.47) | NPY5RKMT2AHTR2BPKMALDH1A1 | |
| Hydrochloric Acid SCHEMBL31596380 | 0.83 | MAPT (0.57) | NPY5RKMT2AHTR2BPKMALDH1A1 | |
| SCHEMBL2674802 | 0.82 | HTR2B (0.55) | NPY5RKMT2AHTR2BPOLBMAPT | |
| SCHEMBL6756134 | 0.82 | NPC1 (0.59) | NPY5RKMT2AHTR2BPOLBMAPT | |
| SCHEMBL724921 | 0.80 | NPC1 (0.62) | NPY5RHTR2BPOLBMAPT | |
| SCHEMBL6757201 | 0.80 | NPC1 (0.62) | NPY5RHTR2BPOLBMAPT | |
| SCHEMBL723402 | 0.80 | NPY5R (0.39) | NPY5RKMT2AHTR2BMAPTPARP1 | |
| SCHEMBL2491336 | 0.79 | HTR2B (0.52) | NPY5RKMT2AHTR2BPKMALDH1A1 | |
| SCHEMBL2106423 | 0.79 | HTR2B (0.52) | NPY5RKMT2AHTR2BPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |