Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248994 | 0.81 | NPC1 (0.59) | RAB9ASMN1; SMN2NPC1POLBMAPT | |
| SCHEMBL13255541 | 0.80 | SMN1; SMN2 (0.71) | KDM4ERAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL24862889 | 0.76 | RAB9A (0.61) | KDM4ERAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL5497597 | 0.76 | ALDH1A1 (0.42) | KDM4ERAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL5374226 | 0.75 | HCAR2 (0.55) | KDM4ERAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL25847892 | 0.75 | RAB9A (0.58) | KDM4ERAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL29844215 | 0.72 | POLB (0.80) | KDM4ERAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL8440269 | 0.72 | POLB (0.80) | KDM4ERAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL1521002 | 0.72 | RAB9A (0.71) | KDM4ERAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL13255493 | 0.71 | ALDH1A1 (0.62) | RAB9ASMN1; SMN2NPC1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6569847-B1 | Inhibitors of cathepsins for treating muscular dystrophy, osteoporosis, rheumatoid arthritis, neuronal or cardiac ischaemia, allergy, or Chagas disease | NAEJA PHARMACEUTICALS INC. (CA) | 2003-05-27 | — | — | US | disclosed |
| EP-1165506-A1 | SUBSTITUTED AZETIDIN-2-ONES AS CYSTEINE PROTEASE INHIBITORS | Naeja Pharmaceutical Inc. (CA) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059881-A1 | SUBSTITUTED AZETIDIN-2-ONES AS CYSTEINE PROTEASE INHIBITORS | NAEJA PHARMACEUTICAL INC (CA) | 2000-10-12 | — | — | WO | disclosed |