Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 19/20 | 0.59 |
| ▸ | ABCC8 | Q09428 | 19/20 | 0.59 |
| ▸ | KCNJ11 | Q14654 | 19/20 | 0.59 |
| ▸ | KCNJ8 | Q15842 | 19/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243802 | 0.94 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7234724 | 0.84 | ABCC9 (0.55) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6435237 | 0.76 | ABCC9 (0.55) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7233225 | 0.75 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6905789 | 0.75 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL6904323 | 0.75 | ABCC9 (0.68) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7098825 | 0.74 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7662609 | 0.73 | ABCC9 (0.65) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7099767 | 0.73 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL5074897 | 0.73 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | claimed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | claimed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | disclosed |