Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 8/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15778955 | 0.82 | PKM (0.40) | PKMTSHRESR2PDE4APDE4B | |
| SCHEMBL20746237 | 0.82 | CRBN (0.51) | PKMTSHRESR2PDE4APDE4B | |
| SCHEMBL25669123 | 0.82 | ALDH1A1 (0.44) | PKMTSHRESR2PDE4APDE4B | |
| SCHEMBL15778957 | 0.82 | PKM (0.40) | PKMTSHRESR2PDE4APDE4B | |
| SCHEMBL2790425 | 0.81 | DDB1 (0.49) | GAAMAPK1MAPTDDB1CRBN | |
| SCHEMBL20036513 | 0.79 | PKM (0.38) | PKMTSHRESR2PDE4APDE4B | |
| SCHEMBL7222002 | 0.78 | DDB1 (0.46) | PKMTSHRESR2ALDH1A1KMT2A | |
| SCHEMBL15624284 | 0.74 | ESR2 (0.60) | ESR2CYP3A4CYP2C9NAAA | |
| SCHEMBL9705417 | 0.74 | TACR1 (0.42) | PKMTSHRESR2PDE4APDE4B | |
| SCHEMBL1198558 | 0.73 | DDB1 (0.43) | PKMESR2GAAMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583133-B1 | Especially against Gram-positive organisms, e.g. methicillin-sensitive (MSSA) and methicillin- resistant (MRSA) staphylococci, enterococci and pneumococci | BASILEA PHARMACEUTICA AG (CH) | 2003-06-24 | — | — | US | disclosed |
| EP-1090013-A1 | PROPENYL CEPHALOSPORIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067255-A1 | PROPENYL CEPHALOSPORIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | WO | disclosed |