Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486258 | 0.91 | EGFR (0.60) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL7243958 | 0.87 | EGFR (0.71) | EGFRERBB2ERBB4 | |
| SCHEMBL7235690 | 0.85 | EGFR (0.55) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL7235693 | 0.84 | EGFR (0.54) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL8525841 | 0.83 | EGFR (0.61) | EGFRERBB2ERBB4FLT3AURKB | |
| SCHEMBL8154615 | 0.81 | EGFR (0.77) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL8143063 | 0.81 | EGFR (0.68) | EGFRERBB2ERBB4CHEK2ROS1 | |
| SCHEMBL28523377 | 0.81 | EGFR (0.51) | EGFR | |
| SCHEMBL8490274 | 0.80 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL8809158 | 0.80 | EGFR (0.67) | EGFRERBB2ERBB4CHEK2ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |