Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 7/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 7/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.56 |
| ▸ | KCNJ8 | Q15842 | 7/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | FGB | P02675 | 1/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | PLEC | Q15149 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6905621 | 0.93 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8TDP1 | |
| SCHEMBL8741578 | 0.89 | ABCC9 (0.65) | ABCC9ABCC8KCNJ11KCNJ8TDP1 | |
| SCHEMBL7235952 | 0.82 | ABCC9 (0.46) | ABCC9ABCC8KCNJ11KCNJ8MAPT | |
| SCHEMBL6431678 | 0.82 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8HSD17B10 | |
| SCHEMBL7236036 | 0.81 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8TDP1 | |
| SCHEMBL7237589 | 0.80 | GPR174 (0.41) | ABCC9ABCC8KCNJ11KCNJ8TDP1 | |
| SCHEMBL6432416 | 0.79 | ABCC9 (0.46) | ABCC9ABCC8KCNJ11KCNJ8MAPT | |
| SCHEMBL6436430 | 0.77 | MEN1 (0.48) | ABCC9ABCC8KCNJ11KCNJ8TDP1 | |
| SCHEMBL6465855 | 0.75 | ABCC9 (0.51) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6432510 | 0.75 | ABCC9 (0.55) | ABCC9ABCC8KCNJ11KCNJ8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | disclosed |