Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231587 | 0.90 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBTDP1RXFP1MAPT | |
| SCHEMBL23070342 | 0.81 | POLB (0.51) | SMN1; SMN2POLBTDP1RXFP1KMT2A | |
| SCHEMBL22737056 | 0.78 | POLB (0.51) | SMN1; SMN2POLBTDP1RXFP1MAPT | |
| SCHEMBL7234307 | 0.77 | MAPT (0.56) | SMN1; SMN2POLBTDP1MAPTRAB9A | |
| SCHEMBL20600028 | 0.76 | MAPT (0.69) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL7234546 | 0.75 | CCR2 (0.51) | POLBL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL24828267 | 0.75 | MAPT (0.67) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL16347393 | 0.75 | CYP19A1 (0.55) | SMN1; SMN2POLBTDP1MAPTL3MBTL1 | |
| SCHEMBL6433289 | 0.75 | NOD2 (0.67) | SMN1; SMN2POLBTDP1RXFP1MAPT | |
| SCHEMBL6432920 | 0.74 | F10 (0.67) | SMN1; SMN2POLBTDP1RXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6548512-B1 | Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-15 | — | — | US | disclosed |