Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 10/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.58 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | ITPR3 | Q14573 | 1/20 | 0.48 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723680 | 1.00 | FTO (0.58) | FTOMAPTMEN1KMT2AHTT | |
| SCHEMBL10682750 | 0.87 | FTO (0.65) | FTOMAPTMEN1KMT2AHTT | |
| SCHEMBL726955 | 0.87 | FTO (0.57) | FTOMAPTMEN1KMT2AHTT | |
| Hydrochloric Acid SCHEMBL1244954 | 0.86 | FTO (0.56) | FTOMAPTMEN1KMT2AHTT | |
| SCHEMBL6232877 | 0.84 | GSTP1 (0.57) | FTOMAPTMEN1KMT2AHTT | |
| SCHEMBL19350417 | 0.83 | FTO (0.65) | FTOMAPTMEN1KMT2AHTT | |
| SCHEMBL9223739 | 0.82 | FTO (0.60) | FTOMAPTMEN1KMT2AHTT | |
| SCHEMBL4142445 | 0.82 | MAPT (0.60) | FTOMAPTMEN1KMT2AHTT | |
| SCHEMBL21194989 | 0.81 | FTO (0.70) | FTOMAPTMEN1KMT2AHTT | |
| SCHEMBL6649726 | 0.80 | FTO (0.72) | FTOMAPTMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180251745-A1 | Compositions and Methods for Modulating Hemostasis | CHILDRENS HOSPITAL PHILADELPHIA (US) | 2018-09-06 | — | — | US | disclosed |
| US-9896676-B2 | Compositions and methods for modulating hemostasis | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2018-02-20 | — | — | US | disclosed |
| US-20160362673-A1 | Compositions and Methods for Modulating Hemostasis | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 2016-12-15 | — | — | US | disclosed |
| US-9410137-B2 | Compositions and methods for modulating hemostasis | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2016-08-09 | — | — | US | disclosed |
| EP-2431390-B1 | Compositions and methods for modulating hemostasis | PHILADELPHIA CHILDREN HOSPITAL (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2423224-B1 | Compositions and methods for modulating hemostasis | PHILADELPHIA CHILDREN HOSPITAL (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-1948690-B1 | Compositions and methods for modulating hemostasis | PHILADELPHIA CHILDREN HOSPITAL (US) | 2014-06-11 | — | — | EP | disclosed |
| US-20140120155-A1 | Compositions and Methods for Modulating Hemostasis | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2014-05-01 | — | — | US | disclosed |
| CN-101356192-B | Compositions and methods for modulating hemostasis | PHILADELPHIA CHILDREN HOSPITAL | 2013-09-11 | — | — | CN | disclosed |
| US-8383386-B2 | Compositions and methods for modulating hemostasis | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2431389-A1 | Compositions and methods for modulating hemostasis | The Children's Hospital of Philadelphia (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-2431390-A1 | Compositions and methods for modulating hemostasis | The Children's Hospital of Philadelphia (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-2423224-A1 | Compositions and methods for modulating hemostasis | The Children's Hospital of Philadelphia (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20090175931-A1 | COMPOSITIONS AND METHODS FOR MODULATING HEMOSTASIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-07-09 | — | — | US | disclosed |
| CN-101356192-A | Compositions and methods for modulating hemostasis | PHILADELPHIA CHILDREN HOSPITAL (US) | 2009-01-28 | — | — | CN | disclosed |