SCHEMBL7237773

SCHEMBL7237773

C#CC(=O)Nc1ccc2c(Nc3ccc(Oc4ccccc4)cc3)ncnc2c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 2/20 0.60
TEK Q02763 1/20 0.60
EGFR P00533 11/20 0.59
ERBB2 P04626 6/20 0.59
CSF1R P07333 4/20 0.57
RIPK2 O43353 1/20 0.55
EPHB2 P29323 1/20 0.55
ERBB4 Q15303 4/20 0.55
TTBK1 Q5TCY1 1/20 0.48
TTBK2 Q6IQ55 1/20 0.48
JAK3 P52333 1/20 0.48
FYN P06241 1/20 0.47
SRC P12931 1/20 0.47
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7243671 0.92 EGFR (0.71) KDRTEKEGFRERBB2RIPK2
SCHEMBL7244335 0.88 EGFR (0.63) EGFRERBB2CSF1RERBB4TTBK1
SCHEMBL7239590 0.87 EGFR (0.56) KDRTEKEGFRERBB2CSF1R
SCHEMBL7234949 0.85 EGFR (0.67) KDRTEKEGFRERBB2CSF1R
SCHEMBL7243052 0.84 EGFR (0.60) KDREGFRERBB2CSF1RERBB4
SCHEMBL7237980 0.83 EGFR (0.84) KDRTEKEGFRERBB2CSF1R
SCHEMBL7117560 0.80 EGFR (0.54) KDREGFRERBB2CSF1RERBB4
SCHEMBL7243449 0.80 EGFR (0.70) KDRTEKEGFRERBB2RIPK2
SCHEMBL7235763 0.80 EGFR (0.73) EGFRERBB2ERBB4TTBK1TTBK2
SCHEMBL8810802 0.78 EGFR (0.77) KDRTEKEGFRERBB2CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127374-A AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS WARNER-LAMBERT COMPANY (US) 2000-10-03 US claimed
WO-1999006378-A1 IRREVERSIBLE INHIBITORS OF TYROSINE KINASES WARNER-LAMBERT COMPANY (US) 1999-02-11 WO claimed
US-6562818-B1 For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis WARNER-LAMBERT COMPANY 2003-05-13 US disclosed
US-6127374-A AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS WARNER-LAMBERT COMPANY (US) 2000-10-03 US disclosed
WO-1999006378-A1 IRREVERSIBLE INHIBITORS OF TYROSINE KINASES WARNER-LAMBERT COMPANY (US) 1999-02-11 WO disclosed