Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.63 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.63 |
| ▸ | ROS1 | P08922 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.63 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.52 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235763 | 0.92 | EGFR (0.73) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL7237773 | 0.88 | KDR (0.60) | EGFRERBB2ERBB4CSF1RTTBK1 | |
| SCHEMBL7237854 | 0.88 | EGFR (0.57) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8814903 | 0.87 | EGFR (0.67) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8810294 | 0.87 | EGFR (0.67) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL7241181 | 0.86 | ERBB2 (0.63) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL7243934 | 0.84 | EGFR (0.85) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8806876 | 0.84 | EGFR (0.63) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8814855 | 0.82 | EGFR (0.83) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL7239406 | 0.82 | EGFR (0.72) | EGFRERBB2ERBB4AURKBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |