Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | TDO2 | P48775 | 2/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238212 | 1.00 | RET (0.55) | RETALKFLT3PDPK1RPS6KA3 | |
| SCHEMBL7543664 | 0.83 | RET (0.52) | RETRPS6KA3TGM2MEN1KMT2A | |
| SCHEMBL11882118 | 0.79 | SMN1; SMN2 (0.57) | RETALKFLT3IDO1TGM2 | |
| SCHEMBL28411784 | 0.79 | GSK3B (0.57) | RETTGM2MEN1KMT2A | |
| SCHEMBL7237107 | 0.77 | RET (0.55) | RETALKFLT3PDPK1RPS6KA3 | |
| SCHEMBL3160648 | 0.74 | PDPK1 (0.44) | FLT3PDPK1TGM2MEN1KMT2A | |
| SCHEMBL3160654 | 0.74 | PDPK1 (0.44) | FLT3PDPK1TGM2MEN1KMT2A | |
| SCHEMBL7238177 | 0.73 | RET (0.57) | RETALKFLT3PDPK1RPS6KA3 | |
| SCHEMBL5893884 | 0.73 | RET (0.40) | RETALKFLT3PDPK1RPS6KA3 | |
| SCHEMBL5893878 | 0.73 | RET (0.40) | RETALKFLT3PDPK1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545035-B1 | Having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-04-08 | — | — | US | disclosed |
| US-6319918-B1 | FOR LYMPHOMA OR SOLID TUMORS TREATMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-11-20 | — | — | US | disclosed |
| EP-1100779-A1 | SUBSTITUTED INDOLINONES, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2001-05-23 | — | — | EP | disclosed |
| WO-1999062882-A1 | SUBSTITUTED INDOLINONES, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-09 | — | — | WO | disclosed |