Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.51 |
| ▸ | PLK4 | O00444 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238205 | 0.83 | RET (0.55) | RETTGM2MEN1KMT2ARPS6KA3 | |
| SCHEMBL7238212 | 0.83 | RET (0.55) | RETTGM2MEN1KMT2ARPS6KA3 | |
| SCHEMBL11882118 | 0.79 | SMN1; SMN2 (0.57) | RETTGM2PLK4PLK1MAPT | |
| SCHEMBL28411784 | 0.79 | GSK3B (0.57) | RETTGM2MEN1KMT2APDGFRB | |
| SCHEMBL14524551 | 0.79 | CCNB2 (0.62) | RETTGM2CES1HSP90AA1CCNB2 | |
| SCHEMBL14446378 | 0.79 | TGM2 (0.61) | RETTGM2CES1HSP90AA1CCNB2 | |
| SCHEMBL29622059 | 0.79 | TGM2 (0.61) | RETTGM2CES1HSP90AA1CCNB2 | |
| SCHEMBL29076767 | 0.79 | TGM2 (0.61) | RETTGM2CES1HSP90AA1CCNB2 | |
| SCHEMBL5873655 | 0.75 | NTRK1 (0.49) | MEN1KMT2AMAPT | |
| SCHEMBL5893904 | 0.75 | NTRK1 (0.49) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180105-A2 | SUBSTITUTED AZA-OXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000055159-A2 | SUBSTITUTED AZA-OXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-09-21 | — | — | WO | disclosed |