Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.55 |
| ▸ | AXL | P30530 | 7/20 | 0.55 |
| ▸ | MERTK | Q12866 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230366 | 0.90 | AXL (0.62) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL30066135 | 0.87 | AXL (0.55) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL1132352 | 0.87 | AXL (0.55) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL6431113 | 0.85 | FGFR2 (0.60) | METAXLKDRPDGFRA | |
| SCHEMBL1132613 | 0.84 | KDR (0.54) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL7227952 | 0.83 | MET (0.55) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL6434507 | 0.82 | FLT1 (0.66) | METAXLKDR | |
| SCHEMBL1132608 | 0.81 | AXL (0.53) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL25029462 | 0.79 | AXL (0.51) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL21201030 | 0.79 | AXL (0.87) | METAXLMERTKKDRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630489-B1 | Quinoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2003-10-07 | — | — | US | disclosed |
| EP-1157008-A1 | QUINOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000050405-A1 | QUINOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-31 | — | — | WO | disclosed |