Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.55 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 6/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238249 | 0.83 | MET (0.55) | METAXLKDRPDGFRAMERTK | |
| SCHEMBL372112 | 0.83 | MET (0.69) | METAXLKDRPDGFRA | |
| SCHEMBL29693544 | 0.83 | MET (0.69) | METAXLKDRPDGFRA | |
| SCHEMBL7237353 | 0.82 | AXL (0.50) | METAXL | |
| SCHEMBL7230366 | 0.82 | AXL (0.62) | METAXLKDRPDGFRBPDGFRA | |
| SCHEMBL7237343 | 0.81 | AXL (0.58) | METAXLKDRPDGFRBPDGFRA | |
| SCHEMBL4459639 | 0.80 | MET (0.65) | METAXLKDRPDGFRA | |
| SCHEMBL6431113 | 0.77 | FGFR2 (0.60) | METAXLKDRPDGFRBPDGFRA | |
| SCHEMBL4365490 | 0.77 | AXL (0.62) | METAXLKDR | |
| SCHEMBL1132290 | 0.76 | MET (0.72) | METAXLKDRPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630489-B1 | Quinoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2003-10-07 | — | — | US | disclosed |
| EP-1157008-A1 | QUINOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000050405-A1 | QUINOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-31 | — | — | WO | disclosed |