Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235837 | 0.92 | TSHR (0.56) | TSHRHSD17B10BCHEHTR3EHTR3B | |
| SCHEMBL7238934 | 0.88 | L3MBTL1 (0.50) | TSHRHSD17B10HTR1AHTR7APP | |
| SCHEMBL7243416 | 0.85 | MEN1 (0.52) | TSHRHSD17B10BCHECHIAACHE | |
| SCHEMBL7232132 | 0.83 | CHIA (0.49) | TSHRHSD17B10BCHEHTR3EHTR3B | |
| SCHEMBL7242857 | 0.83 | CHIA (0.61) | TSHRHSD17B10HTR2CCHIACAPN1 | |
| SCHEMBL7242231 | 0.82 | TSHR (0.47) | TSHRHSD17B10BCHEHTR3EHTR3B | |
| SCHEMBL7241475 | 0.82 | TSHR (0.50) | TSHRHSD17B10HSD11B1CHIACAPN1 | |
| SCHEMBL7232351 | 0.82 | TSHR (0.58) | TSHRHSD17B10HTR1ACHIACAPN1 | |
| SCHEMBL7243837 | 0.82 | CAPN1 (0.58) | TSHRHSD17B10HTR1ACHIACAPN1 | |
| SCHEMBL7239461 | 0.81 | GPR6 (0.48) | TSHRHSD17B10BCHEMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |