Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235837 | 0.89 | TSHR (0.56) | CHIATSHRHSD17B10HTR3EHTR3B | |
| SCHEMBL7243416 | 0.88 | MEN1 (0.52) | CHIATSHRHSD17B10MEN1KMT2A | |
| SCHEMBL7238934 | 0.83 | L3MBTL1 (0.50) | TSHRHSD17B10HTR1AKMT2AHTR7 | |
| SCHEMBL7238307 | 0.83 | TSHR (0.48) | CHIATSHRHSD17B10HTR3EHTR3B | |
| SCHEMBL7242857 | 0.79 | CHIA (0.61) | CHIATSHRHSD17B10HTR2CCAPN1 | |
| SCHEMBL7241454 | 0.79 | BCHE (0.57) | TSHRHTR1AMEN1KMT2AMAPT | |
| SCHEMBL7235226 | 0.79 | HTR3E (0.61) | TSHRHSD17B10HTR3EHTR3BHTR1A | |
| SCHEMBL7241475 | 0.79 | TSHR (0.50) | CHIATSHRHSD17B10HSD11B1CAPN1 | |
| SCHEMBL7239461 | 0.79 | GPR6 (0.48) | TSHRHSD17B10MEN1KMT2AMAPT | |
| SCHEMBL7241407 | 0.79 | CAPN1 (0.65) | CAPN1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |