Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.76 |
| ▸ | FYN | P06241 | 1/20 | 0.76 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.76 |
| ▸ | GRB2 | P62993 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | HSD17B3 | P37058 | 8/20 | 0.68 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263980 | 0.86 | AKR1B1 (1.00) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL17403166 | 0.85 | AKR1B1 (0.72) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL180110 | 0.85 | LCK (0.55) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL13840541 | 0.85 | AKR1B1 (0.76) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL31415321 | 0.85 | LCK (0.55) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL7115912 | 0.84 | LCK (0.54) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL1252272 | 0.83 | HSD17B3 (0.73) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL13839157 | 0.82 | AKR1B1 (0.72) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL20767983 | 0.82 | HSD17B3 (0.68) | LCKFYNAKR1B1GRB2ALDH1A1 | |
| SCHEMBL12729968 | 0.82 | AKR1B1 (0.76) | LCKFYNAKR1B1GRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790536-B2 | Methods for assaying alpha-L-iduronidase enzymatic activity | UNIVERSITY OF WASHINGTON (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150353985-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON (US) | 2015-12-10 | — | — | US | disclosed |
| EP-2191006-B1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIV WASHINGTON (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2012027612-A1 | MASS SPECTROMETRIC COMPOSITIONS AND METHODS FOR LYSOSOMAL STORAGE DISEASE SCREENING | GELB MICHAEL (US) | 2012-03-01 | — | — | WO | disclosed |
| US-20100209951-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2010-08-19 | — | — | US | disclosed |
| US-7759459-B2 | Fluorescent assays for protein kinases | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2010-07-20 | — | — | US | disclosed |
| EP-2191006-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | University of Washington (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026252-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON (US) | 2009-02-26 | — | — | WO | disclosed |
| US-20090005436-A1 | Substituted Aminoalkyl- and Amidoalkyl-Benzopyran Derivatives | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2009-01-01 | — | — | US | disclosed |
| CN-101137638-A | Substituted aminoalkyl-and amidoalkyl-benzopyran derivatives | NEWRON PHARM SPA (IT) | 2008-03-05 | — | — | CN | disclosed |
| EP-1863784-A1 | SUBSTITUTED AMINOALKYL- AND AMIDOALKYL-BENZOPYRAN DERIVATIVES | Newron Pharmaceuticals S.p.A. (IT) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006102958-A1 | SUBSTITUTED AMINOALKYL- AND AMIDOALKYL-BENZOPYRAN DERIVATIVES | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2006-10-05 | — | — | WO | disclosed |
| EP-1062361-A2 | WATER-SOLUBLE COUMARIN FLUORESCENT ENZYME SUBSTRATES | ABBOTT LABORATORIES (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5998593-A | COUMARIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1999-12-07 | — | — | US | disclosed |
| WO-1999046402-A2 | WATER-SOLUBLE COUMARIN FLUORESCENT ENZYME SUBSTRATES | ABBOTT LABORATORIES (US) | 1999-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353985-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | LCK 4717/4885FYN 4354/4885AKR1B1 1920/4885 |
| US-20100209951-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | LCK 4717/4885FYN 4354/4885AKR1B1 1920/4885 |
| US-20090005436-A1 | Substituted Aminoalkyl- and Amidoalkyl-Benzopyran Derivatives | MAOB, MAOA, AOC3 | LCK 3834/4885FYN 1610/4885AKR1B1 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.